Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis

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Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis

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作者：Thorsten Boroviak¹ ; ¹⁰ ; Remco Loos² ; ¹⁰ ; Patrick Lombard¹ ; Junko Okahara⁵ ; Rü ; diger Behr³ ; ⁴ ; Erika Sasaki⁵ ; ⁶ ; Jennifer Nichols¹ ; ⁷ ; Austin Smith¹ ; ⁸ ; ^{austin.smith@cscr.cam.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Paul Bertone¹ ; ² ; ⁹ ; ^{bertone@ebi.ac.uk" class="auth_mail" title="E-mail the corresponding author}
关键词：pluripotency ; inner cell mass ; diapause ; embryonic stem cell ; primate
刊名：Developmental Cell
出版年：2015
出版时间：9 November 2015
年：2015
卷：35
期：3
页码：366-382
全文大小：4279 K

文摘

•: Transcriptome profiling establishes a reference map for early mouse development
•: Lineage-specific RNA-seq captures the full dynamic range of gene expression
•: ESCs and diapaused and preimplantation epiblasts share common pluripotency circuitry
•: Primate early ICM utilizes additional signaling pathways for lineage specification

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