Low density lipoprotein receptor-related protein 1 mediated endocytosis of β1-integrin influences cell adhesion and cell migration

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Low density lipoprotein receptor-related protein 1 mediated endocytosis of β1-integrin influences cell adhesion and cell migration

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作者：Verena K. Rabiej^a ; Thorsten Pflanzner^a ; Timo Wagner^a ; Kristina Goetze^b ; Steffen E. Storck^a ; Johannes A. Eble^c ; Sascha Weggen^d ; Wolfgang Mueller-Klieser^b ; Claus U. Pietrzik^a ; ^{pietrzik@uni-mainz.de" class="auth_mail" title="E-mail the corresponding author}
关键词：LRP1 ; low density lipoprotein receptor related-protein 1 ; Snx17 ; Sorting nexin 17 ; PSD95 ; postsynaptic density protein 95 ; Dab-2 ; disabled homolog 2 ; ECM ; extracellular matrix ; RMS ; rostral migratory stream ; BrdU ; 5-bromo-2-deoxyuridine ; CPZ ; chlorpromazine ; FA ; focal adhesion ; FAK ; focal adhesion kinase ; pFAK Y397 ; focal adhesion kinase phosphorylated at tyrosine 397 ; MMP ; matrix metalloproteases ; SVZ ; subventricular zone ; Pyk2 ; proline-rich tyrosine kinase 2 ; APP ; amyloid precursor protein ; Ra
刊名：Experimental Cell Research
出版年：2016
出版时间：1 January 2016
年：2016
卷：340
期：1
页码：102-115
全文大小：6052 K

文摘

•: LRP1 mediates β1-integrin interaction through its NPxY2 motif.
•: LRP1 β1-integrin interaction influences β1-integrin internalization.
•: LRP1 acts as a potential regulator of cell migration and adhesion.

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