Structural features of subtype-selective EP receptor modulators

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• 作者：Tijana Markovič¹Author Vitae ; Žiga Jakopin¹Author Vitae ; Marija Sollner Dolenc ; Irena Mlinarič-Ra&scaron ; čan ; ^{irena.mlinaric-rascan@ffa.uni-lj.si}Author Vitae
• 刊名：Drug Discovery Today
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：22
• 期：1
• 页码：57-71
• 全文大小：2129 K
• 卷排序：22

文摘

PGE2 receptor subtypes EP1–4 are valuable drug targets. Structural features for subtype-selective activity of EP1–4 receptor modulators are presented. Binding affinities, functional activities and selectivities of presented EP modulators are provided. Recent findings of the clinical value of EP receptor modulators are discussed.