Mild systemic inflammation and moderate hypoxia transiently alter neuronal excitability in mouse somatosensory cortex

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Mild systemic inflammation and moderate hypoxia transiently alter neuronal excitability in mouse somatosensory cortex

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作者：Jé ; rô ; me Mordel^a ; Aminah Sheikh^b ; Simeon Tsohataridis^a ; Patrick O. Kanold^b ; Christoph M. Zehendner^a ; ^c ; Heiko J. Luhmann^a ; ^{luhmann@uni-mainz.de" class="auth_mail" title="E-mail the corresponding author}
关键词：Hypoxia ; Systemic inflammation ; Interleukin-1β ; Multi-electrode array ; Electrophysiology ; Epileptiform activity ; Barrel cortex ; Mouse ; Development ; In vitro
刊名：Neurobiology of Disease
出版年：2016
出版时间：April 2016
年：2016
卷：88
期：Complete
页码：29-43
全文大小：4298 K

文摘

•: Mild hypoxia and systemic inflammation cause epileptiform activity in young cortex.
•: Combination of both insults does not further increase neocortical dysfunction.
•: Hypoxia and inflammation cause transient impairment of glutamatergic function.
•: Functional impairment is transient and cannot be observed in adult mice.

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