Lhx2 Expression in Postmitotic Cortical Neurons Initiates Assembly of the Thalamocortical Somatosensory Circuit

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• 作者：Chia-Fang Wang¹ ; Hsiang-Wei Hsing¹ ; Zi-Hui Zhuang¹ ; Meng-Hsuan Wen¹ ; Wei-Jen Chang² ; Carlos G. Briz³ ; Marta Nieto³ ; Bai Chuang Shyu² ; Shen-Ju Chou¹ ; ⁴ ; ^{schou@gate.sinica.edu.tw}
• 关键词：Lhx2 ; barrel cortex ; layer 4 neurons ; dendritic asymmetry
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：24 January 2017
• 年：2017
• 卷：18
• 期：4
• 页码：849-856
• 全文大小：3236 K
• 卷排序：18

文摘

Lhx2 in postmitotic cortical neurons is critical for barrel cortex development Deletion of Lhx2 in postmitotic neurons leads to somatosensory functional deficits The expression of activity-regulated genes during S1 development requires Lhx2 Lhx2 directly induces Btbd3 to regulate layer 4 neuron dendritic development