Effects of acute caffeine on anxiety-related behavior in rats chronically exposed to the drug, with some evidence of possible withdrawal-reversal

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• 作者：Robert N. Hughes ; ^{rob.hughes@canterbury.ac.nz} ; Nicola J. Hancock
• 关键词：Chronic acute caffeine ; Rats ; Anxiety ; Spatial memory ; Withdrawal reversal ; Sex differences
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：15 March 2017
• 年：2017
• 卷：321
• 期：Complete
• 页码：87-98
• 全文大小：3206 K
• 卷排序：321

文摘

Chronic caffeine decreased activity, increased anxiety and had no effect on spatial memory. Acute caffeine in caffeine-naïve rats increased activity and may have reduced anxiety. Acute caffeine had similar effects on caffeine-exposed rats to those for naïve rats. Some acute effects on caffeine-exposed rats may have involved withdrawal reversal. Some chronic and acute caffeine effects depended on the rats sex.