Synthesis of curcumin/polyrhodanine nanocapsules with antimicrobial properties by oxidative polymerization using the Fenton reaction

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• 作者：Jun-Won Kook^a ; ^b ; Soyeon Kim^a ; Jun-Young Lee^b ; Jung-Hyun Kim^a ; ^{jayhkim@yonsei.ac.kr}
• 关键词：Curcumin ; Polyrhodanine ; Oxidative polymerization ; Fenton reaction ; Minimum inhibitory concentration
• 刊名：Reactive and Functional Polymers
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：109
• 期：Complete
• 页码：125-130
• 全文大小：849 K
• 卷排序：109

文摘

Curcumin exhibits various biological activities; however, its applications are limited because of its poor water solubility. In this study, we describe an encapsulation process that improves this property using a polyrhodanine shell material synthesized by oxidative polymerization. Unlike the previous methods of oxidative polymerizations, we used the Fenton reaction to introduce a FeCl3/H2O2 combination system. By changing the rhodanine monomer ratio, the curcumin/polyrhodanine nanocapsule (CPR-NC) shell thickness could be controlled. The release behavior of curcumin was characterized by UV–Vis spectroscopy over time. Antimicrobial tests with curcumin, polyrhodanine, and CPR-NC were performed to analyze the minimum inhibitory concentration and inhibition zones.