Reassessing APOBEC3G Inhibition by HIV-1 Vif-Derived Peptides

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• 作者：Christopher M. Richards¹ ; ² ; Ming Li¹ ; ² ; Angela L. Perkins³ ; ⁵ ; Anurag Rathore¹ ; ⁶ ; Daniel A. Harki³ ; Reuben S. Harris¹ ; ² ; ⁴ ; ^rsh@umn.edu
• 关键词：A3G ; APOBEC3G ; AID ; activation-induced deaminase ; CBF-β ; core-binding factor beta ; EMSA ; electrophoretic mobility shift assays ; G-to-A ; guanine-to-adenine ; HPLC ; high-performance liquid chromatography ; IC50 ; half maximal inhibitory concentration ; MS ; mass spectrometry ; PCR ; polymerase chain reaction ; ssDNA ; single-stranded DNA ; UDG ; uracil DNA glycosylase ; Vif ; viral infectivity factor
• 刊名：Journal of Molecular Biology
• 出版年：2017
• 出版时间：6 January 2017
• 年：2017
• 卷：429
• 期：1
• 页码：88-96
• 全文大小：781 K
• 卷排序：429

文摘

HIV-1 Vif is a natural APOBEC3G antagonist. Published Vif-derived peptides lack specific APOBEC3G inhibitory activity. Vif peptide 25–39 is simply non-inhibitory. Vif peptide 107–115 inhibits A3G in vitro but is non-specific.