Detection of dexmedetomidine in human breast milk using liquid chromatography-tandem mass spectrometry: Application to a study of drug safety in breastfeeding after Cesarean section

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• 作者：Rika Nakanishi^a ; ¹ ; Manabu Yoshimura^b ; ¹ ; Manabu Suno^a ; ^{sunoma@okayama-u.ac.jp} ; Kento Yamamoto^a ; Haruka Ito^a ; Yohei Uchimine^a ; Takashi Toriumi^b ; Atsushi Kurosawa^c ; Ami Sugawara^c ; Takayuki Kunisawa^c
• 关键词：DEX ; dexmedetomidine ; IS ; internal standard ; LLE ; liquid&ndash ; liquid extraction ; M/P ; milk to plasma concentration ratio ; MRM ; multiple reaction monitoring ; RID ; relative infant dose ; SPE ; solid phase extraction
• 刊名：Journal of Chromatography B
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：1040
• 期：Complete
• 页码：208-213
• 全文大小：474 K
• 卷排序：1040

文摘

An HPLC–MS/MS method for quantification of dexmedetomidine in milk is validated. Dexmedetomidine is undetectable in milk at 24 h after discontinuation of the drug. Breastfeeding can be started at 24 h after dexmedetomidine use in Cesarean section.