Azole-carbodithioate hybrids as vaginal anti-Candida contraceptive agents: Design, synthesis and docking studies

详细信息    查看全文

• 作者：Lalit Kumar ; N ; Lal ; Vikash Kumar ; Amit Sarswat ; Santosh Jangir ; Veenu Bala ; Lokesh Kumar ; Bhavana Kushwaha ; Atindra K. P ; ey ; Mohammad I. Siddiqi ; Praveen K. Shukla ; Jagdamba P. Maikhuri ; Gopal Gupta ; Vishnu L. Sharma
• 关键词：Anti-Candida ; Spermicides ; Imidazole ; Docking ; Carbon disulfide ; Dithiocarbamate
• 刊名：European Journal of Medicinal Chemistry
• 出版年：December, 2013
• 年：2013
• 卷：70
• 期：Complete
• 页码：68-77
• 全文大小：1747 K

文摘

Azole and carbodithioate hybrids were synthesized as alkyl 1H-azole-1-carbodithioates (7-27) and evaluated for spermicidal/microbicidal activities against human sperm, Trichomonas vaginalis and Candida species. Seventeen compounds (7-14, 16-18 and 20-25) showed spermicidal activity at MEC 1.0% (w/v) and permanently immobilized 100% normal human spermatozoa within 鈭?0聽s. Seventeen compounds (7-11, 13-18 and 20-25) exhibited anti-Candida activity (IC₅₀ 1.26-47.69聽渭g/mL). All compounds were devoid of bactericidal activity against four bacterial strains (50.00聽渭g/mL) and antiprotozoal activity against Trichomonas vaginalis (200.00聽渭g/mL). Four promising compounds (10, 17, 20 and 22) have better safety profile as compared to Nonoxynol-9 (N-9). Docking study was done to visualize the possible interaction of designed scaffold with prospective receptor (Cyp51) of Candida albicans.