Two distinct symptom-based phenotypes of depression in epilepsy yield specific clinical and etiological insights

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• 作者：Genevieve Rayner^a ; ^b ; ^{raynerg@unimelb.edu.au} ; Graeme D. Jackson^b ; ^c ; Sarah J. Wilson^a ; ^b ; ^c
• 关键词：AMI ; Autobiographical Memory Interview ; ESI-55 ; Epilepsy Surgery Inventory &mdash ; 55 Items ; FACES-IV ; Family Adaptability and Cohesion Scale &mdash ; Fourth Edition ; FSIQ ; Full-Scale Intelligence Quotient ; DSM-IV ; Diagnostic and Statistical Manual of Mental Disorders &mdash ; Fourth Edition ; ILAE ; International League Against Epilepsy ; NDDI-E ; Neurological Disorders Depression Inventory &mdash ; Epilepsy ; PHQ-GAD-7 ; Patient Health Questionnaire &mdash ; Generalized Anxiety Disorder &mdash ; 7 Items
• 刊名：Epilepsy & Behavior
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：64
• 期：part_PB
• 页码：336-344
• 全文大小：818 K
• 卷排序：64

文摘

This study revealed distinct symptom-based phenotypes of depression in epilepsy. A Cognitive Depression phenotype (base rate = 17%) was predominant. This was typified by self-critical cognitions, dysphoria, and diffuse memory deficits. A Somatic Depression phenotype (base rate = 7%) was typified by vegetative symptoms and anhedonia. Care implications include better diagnosis and treatment of depression in epilepsy.