Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration

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Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration

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作者：Stephen M. Richardson^a ; ¹ ; ^{s.richardson@manchester.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Gauthaman Kalamegam^b ; ¹ ; ^{kgauthaman@kau.edu.sa" class="auth_mail" title="E-mail the corresponding author} ; Peter N. Pushparaj^b ; ^{peter.n.pushparaj@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Csaba Matta^c ; ^{c.matta@surrey.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Adnan Memic^d ; ^{amemic@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ali Khademhosseini^e ; ^f ; ^g ; ^h ; ^{alik@rics.bwh.harvard.edu" class="auth_mail" title="E-mail the corresponding author} ; Reza Mobasheriⁱ ; ^{reza.mobasheri@imperial.nhs.uk" class="auth_mail" title="E-mail the corresponding author} ; Fabian L. Polettiⁱ ; ^{Fabian.poletti@imperial.nhs.uk" class="auth_mail" title="E-mail the corresponding author} ; Judith A. Hoyland^a ; ^k ; ^{judith.a.hoyland@manchester.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Ali Mobasheri^c ; ^j ; ^b ; ^{a.mobasheri@surrey.ac.uk" class="auth_mail" title="E-mail the corresponding author}
关键词：Mesenchymal stem cell (MSC) ; Regenerative medicine ; Tissue engineering ; Low back pain (LBP) ; Intervertebral disc (IVD) ; IVD degeneration ; Biological therapy ; Cellular therapy ; Articular cartilage ; Osteoarthritis (OA) ; Umbilical cord ; Wharton&rsquo ; s Jelly stem cell (WJSC) ; Adipose-derived stem cell (AD-MSC)
刊名：Methods
出版年：2016
出版时间：15 April 2016
年：2016
卷：99
期：Complete
页码：69-80
全文大小：1505 K

文摘

•: Age-related musculoskeletal disorders represent a major cause of morbidity globally.
•: Development of cell-based therapies for musculoskeletal disorders is proliferating.
•: MSCs in bone marrow, adipose tissue and umbilical cord are used for cartilage repair.
•: Adipose-derived MSCs and intervertebral disc (IVD) progenitors have repair potential.
•: This review focuses on stem cell based therapeutics for cartilage and IVD repair.