Insecticide sensitivity of native chloride and sodium channels in a mosquito cell line

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Insecticide sensitivity of native chloride and sodium channels in a mosquito cell line

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作者：Lacey J. Jenson^a ; ^b ; Troy D. Anderson^b ; Jeffrey R. Bloomquist^a ; ^{jbquist@epi.ufl.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：CACC ; calcium-activated chloride channel ; CI ; 95% confidence intervals ; DIDS ; 4 ; 4&prime ; -diisothiocyano-2 ; 2&prime ; -stilbenedisulfonic acid ; EC50 ; effective concentration at half maximal effect ; IC50 ; inhibitory concentration at 50% of initial effect ; FNV ; fenvalerate ; GABA ; gamma-aminobutyric acid ; TTX ; tetrodotoxin ; VSCC ; voltage-sensitive chloride channel ; VTD ; veratridine
刊名：Pesticide Biochemistry and Physiology
出版年：2016
出版时间：June 2016
年：2016
卷：130
期：Complete
页码：59-64
全文大小：731 K

文摘

•: Sua1B cell growth was inhibited by insecticides.
•: Cl⁻ currents were enhanced in the presence of lindane in a Ca⁺⁺ dependent manner.
•: DIDS blocked Cl⁻ currents in most cells, but some were insensitive.
•: Type 2, but not type 1 pyrethroids also significantly reduced Cl⁻ currents.
•: A type of “electrically silent” Na⁺ channels may exist in Sua1B cells.

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