Molecular regulation of LHCGR expression by miR-122 during follicle growth in the rat ovary

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• 作者：Bindu Menon ; Thippeswamy Gulappa ; K.M.J. Menon ; ^{kmjmenon@umich.edu}
• 关键词：Luteinizing hormone receptor ; mRNA binding protein ; microRNA ; miR-122 ; Follicle stimulating hormone ; Estradiol
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：442
• 期：Complete
• 页码：81-89
• 全文大小：1107 K
• 卷排序：442

文摘

LH receptor (LHCGR) is regulated by the microRNA, miR-122 during follicle development. miR-122 is downregulated during FSH-induced LHCGR upregulation in rat granulosa cells. miR-122 overexpression inhibits FSH-induced LHCGR upregulation by increasing the expression and binding activity of LRBP.