文摘
Cyclo-diBA, the cyclic product formed from bisphenol A and bisphenol A diglycidyl ether during production of epoxy resins, was measured in canned food using reversed phase HPLC with fluorescence detection. Half (9 of 17) of the samples of canned fish in oil collected in April 2010 contained cyclo-diBA with an average concentration of 1025 ¦Ìg/kg and a maximum of 1980 ¦Ìg/kg. In September 2012, cyclo-diBA was detectable (>25 ¦Ìg/kg) in merely 13 from 44 such products; the average concentration in these was 807 ¦Ìg/kg and the maximum now reached 2640 ¦Ìg/kg. Fish in brine contained far less cyclo-diBA. The majority of the canned meat products contained cyclo-diBA at a mean concentration of 477 ¦Ìg/kg and a maximum of 1050 ¦Ìg/kg. All prepared meals, such as ravioli or soups, contained cyclo-diBA, with a mean at 287 ¦Ìg/kg. In canned tomatoes, peas and other vegetables in water or fruits in syrup, no cyclo-diBA was detected (<25 ¦Ìg/kg). Since no experimental toxicity data are available except for its cytotoxicity, an in silico hazard profiling was performed. Cyclo-diBA seems to be stable and of low reactivity. There is indication for considerable oral bioavailability and for the potential to accumulate in the human body. Cyclo-diBA can be metabolized into cyclic and acyclic compounds. Based on SAR assessment for cyclo-diBA and read-across from BADGE to linear cyclo-diBA metabolites, genotoxic effects are improbable. Specific binding of cyclo-diBA to nuclear receptors, such as ER¦Â, can be predicted, indicating a potential endocrine-disrupting potency. The limit by the EFSA guidelines of 50 ¦Ìg/person/d for compounds shown not to be genotoxic as well as the TTC-based Cramer structural class III value of 90 ¦Ìg/person/d could be exceeded several fold by high consumers of canned fish in oil with high brand loyalty. As a consequence, risk reduction measures were taken.
