Nitric oxide-repressed Forkhead factor FoxE1 expression is involved in the inhibition of TSH-induced thyroid peroxidase levels

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Nitric oxide-repressed Forkhead factor FoxE1 expression is involved in the inhibition of TSH-induced thyroid peroxidase levels

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作者：Marí ; a del Mar Montesinos<sup>1sup> ; Juan Pablo Nicola<sup>1sup> ; Magalí ; Nazar ; Victoria Peyret ; Ariel Maximiliano Lucero ; Claudia Gabriela Pellizas ; Ana Marí ; a Masini-Repiso<sup> ; sup><sup>amasini@fcq.unc.edu.ar" class="auth_mail" title="E-mail the corresponding authorsup>
关键词：Thyroperoxidase (TPO) ; Nitric oxide (NO) ; Thyroid stimulating hormone (TSH) ; Forkhead box protein E1 (FoxE1)
刊名：Molecular and Cellular Endocrinology
出版年：2016
出版时间：15 January 2016
年：2016
卷：420
期：Complete
页码：105-115
全文大小：1494 K

文摘

•: Nitric oxide donors decrease TSH-stimulated thyroid peroxidase (TPO) expression.
•: Nitric oxide-repressed TSH-stimulated TPO expression involves the cGMP/cGK pathway.
•: Nitric oxide inhibits FoxE1-dependent TPO expression.
•: Nitric oxide decreases TSH-induced FoxE1 at the transcripcional level.
•: FoxE1 overexpression restores nitric oxide donors-repressed TPO expression.

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