Loss of CD28 within CD4⁺ T cell subsets from cervical cancer patients is accompanied by the acquisition of intracellular perforin, and is further enhanced by NKG2D expression

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• 作者：Marta Escarra-Senmarti^a ; ^{escarra.marta@gmail.com} ; Miriam Ruth Bueno-Topete^a ; ^{bueno@cencar.udg.mx} ; Luis Felipe Jave-Suarez^b ; ^{lfjave@yahoo.com} ; Eduardo Gomez-Bañ ; uelos^c ; ^{reumatologo.eduardo@gmail.com} ; Jorge Gutierrez-Franco^a ; ^{qfb_jorgeguf@hotmail.com} ; Natali Vega-Magañ ; a^a ; ^{natalivega.dcb@gmail.com} ; Adriana Aguilar-Lemarroy^b ; ^{adry.aguilar.lemarroy@gmail.com} ; Ana Laura Pereira-Suarez^d ; ^{analauraps@hotmail.com} ; Jesse Haramati^e ; ^{jharamati@gmail.com} ; Susana del Toro-Arreola^a ; ^d ; ^{susana@cucs.udg.mx}
• 关键词：CC ; cervical cancer ; HPV ; human papillomavirus ; NKG2D ; natural-killer group 2 ; member D ; FS ; forward scatter ; SS ; side scatter ; PBMCs ; peripheral blood mononuclear cells
• 刊名：Immunology Letters
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：182
• 期：Complete
• 页码：30-38
• 全文大小：1598 K
• 卷排序：182

文摘

CD4+ T cell characterization with or without CD28 and NKG2D in cervical cancer is proposed. CD4+CD28null T cells, many of them NKG2D+, are expanded in selected cervical cancer samples. The lack of immunoregulatory markers is a signature for the CD4+CD28null T cells. Strong perforin expression is a characteristic of the CD4+CD28null T cell population. The presence of NKG2D enhances the expression of perforin in CD4+CD28null T cells.