Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis

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Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis

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作者：Dah Ihm Kim^a ; ^b ; ¹ ; ^{daim530@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; Ki Hoon Lee^a ; ^b ; ² ; ^{alca2003@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; Amr Ahmed Gabr^b ; ³ ; ^{amr.ahmed@cu.edu.eg" class="auth_mail" title="E-mail the corresponding author} ; Gee Euhn Choi^a ; ^b ; ⁴ ; ^{oroforof0105@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; Jun Sung Kim^a ; ^b ; ⁴ ; ^{jskim7223@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; So Hee Ko^a ; ^b ; ⁴ ; ^{sohi33@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; Ho Jae Han^a ; ^b ; ¹ ; ^{hjhan@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author}
关键词：Aβ ; Amyloid β ; AD ; Alzheimer's disease ; Akt ; protein kinase B ; AraC ; cytosine arabinoside ; ATP ; adenosine triphosphate ; CaM ; calmodulin ; CaMKIα ; Ca2 ; +/calmodulin-dependent kinase type 1 alpha ; CaMKII ; Ca2 ; +/calmodulin-dependent kinase type II ; CDK ; cyclin dependent kinase ; DMEM ; Dulbecco Modified Eagle Medium ; Drp1 ; dynamin-related protein ; ERK ; extracellular signal-regulated kinase ; ETC ; electron transport chain ; FBS ; fetal bovine serum ; Fis1 ; mitochondrial fission protein1 ; FITC ; flu
刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
出版年：2016
出版时间：November 2016
年：2016
卷：1863
期：11
页码：2820-2834
全文大小：2895 K

文摘

•: Aβ induces Drp1 S616 phosphorylation via sustained Akt pathway.
•: Impaired autophagic function induced by Aβ exacerbates mitochondrial dysfunction.
•: Amyloid-β (Aβ) induces neuronal cell death via excessive mitochondrial fission.

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