ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target

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ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target

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作者：Peter T. Nelson^a ; ^b ; ^{pnels2@email.uky.edu" class="auth_mail" title="E-mail the corresponding author} ; Gregory A. Jicha^a ; ^c ; Wang-Xia Wang^a ; Eseosa Ighodaro^a ; Sergey Artiushin^a ; Colin G. Nichols^d ; David W. Fardo^a ; ^e
关键词：SUR2A ; SUR2B ; SUR2Ab ; SUR1 ; Neuropathology ; GWAS ; Hippocampus ; Oldest-old ; Arteriolosclerosis ; ABCC8
刊名：Ageing Research Reviews
出版年：2015
出版时间：November 2015
年：2015
卷：24
期：part_PB
页码：111-125
全文大小：2958 K

文摘

•: ABCC9 encodes SUR2, a metabolic sensor protein that has been shown to change (expression and function) in aging.
•: ABCC9 is also strongly implicated in vasoregulation.
•: ABCC9 has been implicated in neurologic diseases including sleep, depression, and hippocampal sclerosis of aging (HS-Aging).
•: HS-Aging is a prevalent and impactful brain disease of advanced old age.
•: ABCC9/SUR2 is a potentially druggable target that may provide a future therapeutic strategy.

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