Changes in synaptic plasticity and expression of glutamate receptor subunits in the CA1 and CA3 areas of the hippocampus after transient global ischemia

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Changes in synaptic plasticity and expression of glutamate receptor subunits in the CA1 and CA3 areas of the hippocampus after transient global ischemia

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作者：Xin-Jia Han^a ; ^b ; Zhong-Shan Shi^a ; ^b ; Luo-Xing Xia^a ; Li-Hui Zhu^a ; Ling Zeng^a ; Jun-Hua Nie^a ; Zao-Cheng Xu^c ; Yi-Wen Ruan^a ; ^b ; ^d ; ^e ; ^f ; ^{tyiwen@jnu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; ^{yiwenruan@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
关键词：AAD ; asymmetric axodendritic synapses ; AAS ; asymmetric axospinous synapses ; AMPA ; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ; AMPARs ; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors ; BDNF ; brain-derived neurotrophic factor ; CAMKII ; calcium/calmodulin-dependent protein kinase II ; CCA ; common carotid arteries ; CREB ; cAMP response element binding protein ; DC ; direct current ; DSR ; distal stratum radium ; FD ; fluorescence intensity ; ID ; ischemic depolarization ; NMDA ; N-methyl-
刊名：Neuroscience
出版年：2016
出版时间：7 July 2016
年：2016
卷：327
期：Complete
页码：64-78
全文大小：4567 K

文摘

•: Transient global ischemia induced changes in number of synapses and thickness of PSD in the CA1 area but not CA3 region.
•: The NR2B/NR2A and GluR1/GluR2 ratios increased in the CA1 area but not CA3 region after ischemia.
•: Changes in synaptic morphology and glutamate receptor subunits in the CA1 area may be related to ischemic-neuronal death.