Impact of high-dose statins on vitamin D levels and platelet function in patients with coronary artery disease

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• 作者：Monica Verdoia^a ; ^{ve.monica@libero.it} ; Patrizia Pergolini^b ; Roberta Rolla^b ; Matteo Nardin^a ; ^c ; Alon Schaffer^a ; Lucia Barbieri^a ; ^d ; Veronica Daffara^a ; Paolo Marino^a ; Giorgio Bellomo^b ; Harry Suryapranata^e ; Giuseppe De Luca^a ; ^{giuseppe.deluca@maggioreosp.novara.it} ; On behalf of the Novara Atherosclerosis Study Group (NAS)
• 关键词：Vitamin D ; Statins ; Platelet aggregation ; Coronary artery disease
• 刊名：Thrombosis Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：150
• 期：Complete
• 页码：90-95
• 全文大小：383 K
• 卷排序：150

文摘

Cardioprotective pleiotropic effects of statins are yet undefined Vitamin D displays antinflammatory and antithrombotic properties potentially mediating the anti-atherogenic benefits of statins We describe how the addition of a high-intensity statin provided a vitamin D raise in 246 patients with coronary artery disease Patients displaying the largest increase in vitamin D with statins showed a higher platelet inhibition on dual antiplatelet therapy.