In silico multiple-targets identification for heme detoxification in the human malaria parasite Plasmodium falciparum

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In silico multiple-targets identification for heme detoxification in the human malaria parasite Plasmodium falciparum

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作者：Suthat Phaiphinit^a ; Sittiporn Pattaradilokrat^b ; Chidchanok Lursinsap^a ; Kitiporn Plaimas^a ; ^{kplaimas@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; ^{kitiporn.p@chula.ac.th" class="auth_mail" title="E-mail the corresponding author}
关键词：Antimalarial drug targets ; Flux balance analysis ; Plasmodium falciparum ; Red blood cell ; Metabolic network ; Multiple drug targets ; Drug resistance
刊名：Infection, Genetics and Evolution
出版年：2016
出版时间：January 2016
年：2016
卷：37
期：Complete
页码：237-244
全文大小：476 K

文摘

•: Propose new targets for antimalarial drugs
•: Optimize the number of multiple drug targets
•: More realistic metabolic model of the malaria parasite in human red blood cell

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