Synthesis of new secretory phospholipase A<sub>2</sub>-inhibitory indole containing isoxazole derivatives as anti-inflammatory and anticancer agents

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Synthesis of new secretory phospholipase A₂-inhibitory indole containing isoxazole derivatives as anti-inflammatory and anticancer agents

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作者：Srinivasa Rao Pedada^a ; ¹ ; ² ; Nagendra Sastry Yarla^b ; ² ; Pawan J. Tambade^c ; Bhadrapura Lakkappa Dhananjaya^d ; Anupam Bishayee^e ; Kalle M. Arunasree^f ; Gundala Harold Philip^g ; Gangappa Dharmapuri^f ; ^g ; Gjumrach Aliev^h ; ⁱ ; ^j ; Swathi Putta^k ; Gururaja Rangaiah^l ; ^{dr.gururaja@gmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Indole ; Isooxazole ; Secretory phospholipase A2 ; Anticancer ; Anti-inflammatory activity
刊名：European Journal of Medicinal Chemistry
出版年：2016
出版时间：13 April 2016
年：2016
卷：112
期：Complete
页码：289-297
全文大小：1086 K

文摘

•: A series of new indole containing isoxazole derivatives (10a–10o) is synthesized.
•: These compounds (10a–10o) showed significant sPLA₂-inhibition activity.
•: 10o showed potent sPLA₂ inhibition activity among other compounds.
•: 10o exhibited in vivo antiinflammatory activity in mice.
•: 10o showed in vitro anticancer activity against MCF-7 breast and DU145 prostate cancer cells.

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