Cell surface syndecan-1 contributes to binding and function of macrophage migration inhibitory factor (MIF) on epithelial tumor cells

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Cell surface syndecan-1 contributes to binding and function of macrophage migration inhibitory factor (MIF) on epithelial tumor cells

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作者：Tobias Pasqualon^a ; Hongqi Lue^b ; Sabine Groening^b ; ^c ; Jessica Pruessmeyer^a ; Holger Jahr^d ; Bernd Denecke^e ; Jü ; rgen Bernhagen^b ; ^f ; ^g ; Andreas Ludwig^a ; ^{aludwig@ukaachen.de" class="auth_mail" title="E-mail the corresponding author}
关键词：Proteoglycan ; Syndecan ; Chemokine ; Heparin ; Tumor cell migration ; Macrophage migration inhibitory factor ; Metalloproteinase
刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
出版年：2016
出版时间：April 2016
年：2016
卷：1863
期：4
页码：717-726
全文大小：2053 K

文摘

•: Macrophage migration inhibitory factor (MIF) binds to surface proteoglcyans on epithelial tumor cells.
•: Syndecan-1 is the most relevant MIF binding proteoglycan.
•: MIF binding is regulated by metalloproteinase-mediated syndecan-1 shedding.
•: MIF-induced epithelial tumor cell migration is syndecan-1 dependent.
•: The interaction of syndecan-1 and MIF may be relevant for tumor metastasis.

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