Syndecan4 coordinates Wnt/JNK and BMP signaling to regulate foregut progenitor development

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Syndecan4 coordinates Wnt/JNK and BMP signaling to regulate foregut progenitor development

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作者：Zheng Zhang ; Scott A. Rankin ; Aaron M. Zorn ; ^{aaron.zorn@cchmc.org" class="auth_mail" title="E-mail the corresponding author}
关键词：Syndecan ; Extracellular matrix ; Fibronectin ; Fzd ; Wnt ; BMP ; Foregut ; Progenitor ; Endoderm ; Xenopus ; hhex
刊名：Developmental Biology
出版年：2016
出版时间：1 August 2016
年：2016
卷：416
期：1
页码：187-199
全文大小：4963 K

文摘

•: The proteoglycan Syndecan4 is essential for Xenopus foregut progenitor development.
•: Syndecan4 coordinates Wnt/JNK and BMP/Smad1 signaling to control foregut development progenitors.
•: Syndecan4 cooperates with Fzd7 to promote non-canonical Wnt/JNK signal transduction.
•: Syndecan4 is for the Fibronectin matrix the foregut mesendoderm.
•: Syndecan4 promotes Fibronectin-dependent BMP signaling feedback loop in the foregut.

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