Maternal choline supplementation in a mouse model of Down syndrome: Effects on attention and nucleus basalis/substantia innominata neuron morphology in adult offspring

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• 作者：Brian E. Powers^a ; Christy M. Kelley^c ; Ramon Velazquez^b ; Jessica A. Ash^a ; Myla S. Strawderman^a ; Melissa J. Alldred^d ; ^e ; Stephen D. Ginsberg^d ; ^e ; ^f ; Elliott J. Mufson^c ; ^&dagger ; ; Barbara J. Strupp^a ; ^b ;
• 关键词：AD ; Alzheimer&rsquo ; s disease ; BFCNs ; basal forebrain cholinergic neurons ; ChAT ; choline acetyltransferase ; DS ; Down syndrome ; MCS ; maternal choline supplementation ; MSN ; medial septal nucleus ; NBM/SI ; nucleus basalis of Meynert/substantia innominata ; p75NTR ; pan-neurotrophin receptor p75NTR ; PB ; phosphate buffer ; TBS ; Tris-buffered saline
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：6 January 2017
• 年：2017
• 卷：340
• 期：Complete
• 页码：501-514
• 全文大小：2211 K
• 卷排序：340

文摘

Ts65Dn mice demonstrated impaired learning and attention, which were ameliorated by maternal choline supplementation (MCS). MCS improved attention in both Ts65Dn and 2N offspring, but did not alter morphology of cholinergic neurons in the NBM/SI. Ts65Dn mice exhibited an increased number of BFCNs in the NMB/SI and a decreased number of BFCNs in the MSN. The soma volume of BFCNs in both basal forebrain regions was significantly larger in Ts65Dn mice, relative to 2N controls. Attentional performance was inversely associated with BFCN volume, and positively associated with BFCN density.