The role of spinal interleukin-1β and astrocyte connexin 43 in the development of mirror-image pain in an inflammatory pain model

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The role of spinal interleukin-1β and astrocyte connexin 43 in the development of mirror-image pain in an inflammatory pain model

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作者：Hoon-Seong Choi^a ; Dae-Hyun Roh^b ; Seo-Yeon Yoon^c ; Soon-Gu Kwon^b ; Sheu-Ran Choi^a ; Suk-Yun Kang^d ; Ji-Young Moon^d ; Ho-Jae Han^a ; Hyun-Woo Kim^e ; Alvin J. Beitz^f ; Jang-Hern Lee^a ; ^{jhl1101@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author}
关键词：Mirror-image pain ; Interleukin-1&szlig ; Astrocyte ; Connexin 43
刊名：Experimental Neurology
出版年：2017
出版时间：January 2017
年：2017
卷：287
期：part_P1
页码：1-13
全文大小：1275 K

文摘

•: CA rats showed a delayed increase of contralateral MA and spinal Cx43 expression.
•: Blocking of spinal IL-1β advanced the development of contralateral MA.
•: Blocking of spinal IL-1β upregulated the spinal Cx43 expression.
•: Inhibition of astrocyte GJ restored the IL-1ra-evoked early contralateral MA and spinal Cx43 expression.

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