Raman spectroscopy and capillary zone electrophoresis for the analysis of degradation processes in commercial effervescent tablets containing acetylsalicylic acid and ascorbic acid

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• 作者：Sabine Neuberger^a ; Kevin Joo&szlig ; ^a ; Dirk Flottmann^a ; Gerhard Scriba^b ; Christian Neusü ; &szlig ; ^a ; ^{Christian.Neusuess@hs-aalen.de}
• 关键词：AA ; ascorbic acid ; APIs ; active pharmaceutical ingredients ; ASA ; acetylsalicylic acid ; BGE ; background electrolyte ; DHAA ; dehydroascorbic acid ; diAc-AA ; diacetylated ascorbic acid ; IS ; internal standard ; mAc-AA ; monoacetylated ascorbic acid ; MRSD ; mean relative standard deviation ; NSA ; 2-naphthalenesulfonic acid ; PCA ; principal component analysis ; PC ; principal component ; RH ; relative humidity ; RSD ; relative standard deviation ; SA ; salicylic acid
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：134
• 期：Complete
• 页码：122-129
• 全文大小：1348 K
• 卷排序：134

文摘

Degradation of effervescent tablets at high humidity by Raman spectroscopy and CZE. Comparison of two analytical techniques for the characterization of pharmaceuticals. Quantification of active pharmaceutical ingredients and degradation products by CZE. Fast detection of degradation of effervescent tablets by Raman spectroscopy and PCA. Quantification of mono- and diacetylated ascorbic acid in effervescent tablets by CZE.