Facile regioselective synthesis of novel bioactive thiazolyl-pyrazoline derivatives via a three-component reaction and their antimicrobial activity

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• 作者：Bahman Sharifzadeh^a ; Nosrat O. Mahmoodi^a ; ^{mahmoodi@guilan.ac.ir} ; Manouchehr Mamaghani^a ; Khalil Tabatabaeian^a ; Alireza Salimi Chirani^b ; Iraj Nikokar^c
• 关键词：Thiazolyl-pyrazoline ; Chalcone ; Thiosemicarbazide ; Three-component ; Antibacterial activity
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2013
• 出版时间：15 January, 2013
• 年：2013
• 卷：23
• 期：2
• 页码：548-551
• 全文大小：477 K

文摘

A series of novel 2-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)-4-phenylthiazoles have been prepared by a three-component cyclo-condensation of various chalcones, thiosemicarbazide and phenacyl bromide. The easy work-up of the products, rapid reaction, and mild conditions are notable features of this protocol. The reaction was efficiently catalyzed in one-pot by a few drops of HCl in EtOH under reflux conditions providing the title compounds in moderate to high yields. The antibacterial activity of the selected products was examined. Some products exhibit promising activities.