Haploidentical and Matched Sibling Donor Hematopoietic Cell Transplantation for Patients with HLA-Homozygous Haplotypes

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Haploidentical and Matched Sibling Donor Hematopoietic Cell Transplantation for Patients with HLA-Homozygous Haplotypes

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作者：Junya Kanda¹ ; Kazuhiro Ikegame² ; Shigeo Fuji³ ; Mineo Kurokawa⁴ ; Heiwa Kanamori⁵ ; Takahiro Fukuda³ ; Kazuteru Ohashi⁶ ; Jun Ishikawa⁷ ; Hiroyasu Ogawa² ; Masami Inoue⁸ ; Tatsuo Ichinohe⁹ ; Yoshiko Atsuta¹⁰ ; ¹¹ ; Yoshinobu Kanda¹ ; ¹² ; ^{ycanda-tky@umin.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; on behalf of the HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation
关键词：Donor selection ; HLA-homozygous haplotypes ; HLA mismatch ; GVHD ; Overall survival ; Host-versus-graft direction
刊名：Biology of Blood and Marrow Transplantation
出版年：2016
出版时间：November 2016
年：2016
卷：22
期：11
页码：2031-2037
全文大小：947 K

文摘

•: For patients with homozygous haplotypes, haploidentical donors have no GVH mismatch.
•: Transplant outcomes were similar between hetero-to-homo and matched sibling HCT.
•: Incidences of acute GVHD and NRM were low after homo-to-homo transplantation.
•: Hetero-to-homo transplantation without T cell depletion is a viable option.

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