Origin and dynamic lineage characteristics of the developing Drosophila midgut stem cells

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Origin and dynamic lineage characteristics of the developing Drosophila midgut stem cells

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作者：Shigeo Takashima ; Patrick Aghajanian ; Amelia Younossi-Hartenstein ; Volker Hartenstein ; ^{volkerh@mcdb.ucla.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Stem cell ; Midgut ; Drosophila ; Metamorphosis ; Prospero ; Notch
刊名：Developmental Biology
出版年：2016
出版时间：15 August 2016
年：2016
卷：416
期：2
页码：347-360
全文大小：12834 K

文摘

•: Drosophila presumptive intestinal stem cells (pISCs) are formed around 0–4 h APF.
•: iPSCs are motile, mesenchymal cells.
•: pISCs undergo three parasynchronous mitotic divisions during the pupal period.
•: pISCs generate endocrine cells, but not enterocytes during the pupal period.
•: Prospero, modulated by Notch activity, specifies endocrine fate in pISCs.

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