Randomized study of the clinical effects of ω-3 fatty acid-containing enteral nutrition support during neoadjuvant chemotherapy on chemotherapy-related toxicity in patients with esophageal cancer

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• 作者：Hiroshi Miyata ; M.D.^a ; ^b ; ^{Hmiyata@gesurg.med.osaka-u.ac.jp} ; Masahiko Yano ; M.D.^b ; Takushi Yasuda ; M.D.^c ; Makoto Yamasaki ; M.D.^a ; Kohei Murakami ; M.D.^a ; Tomoki Makino ; M.D.^a ; Kohei Nishiki ; M.D.^c ; Keijiro Sugimura ; M.D.^b ; Masaaki Motoori ; M.D.^b ; Osamu Shiraishi ; M.D.^c ; Masaki Mori ; M.D.^a ; Yuichiro Doki ; M.D.^a
• 关键词：Esophageal cancer ; Chemotherapy ; Enteral nutrition ; Toxicity ; Adverse effect ; ω-3 fatty acid
• 刊名：Nutrition
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：33
• 期：Complete
• 页码：204-210
• 全文大小：720 K
• 卷排序：33

文摘

Little is known about the effect of ω-3 fatty acids on reducing chemotherapy-related toxicities. A randomized study was conducted to compare ω-3–rich enteral nutrition (EN) with ω-3–poor EN in patients undergoing cisplatin-based chemotherapy. ω-3–rich EN reduced the incidence of chemotherapy-related mucosal toxicities and had a hepatoprotective effect during chemotherapy.