Therapeutic efficacy of peramivir against H5N1 highly pathogenic avian influenza viruses harboring the neuraminidase H275Y mutation

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• 作者：Masanori Kobayashi^a ; ¹ ; ² ; Makoto Kodama^a ; ¹ ; Takeshi Noshi^a ; Ryu Yoshida^a ; Takushi Kanazu^b ; Naoki Nomura^c ; ^f ; Kosuke Soda^c ; ^g ; Norikazu Isoda^c ; ^e ; ^h ; Masatoshi Okamatsu^c ; Yoshihiro Sakoda^c ; ^e ; Yoshinori Yamano^a ; Akihiko Sato^a ; ^d ; ^{akihiko.sato@shionogi.co.jp} ; Hiroshi Kida^d ; ^e
• 关键词：Influenza ; H5N1 ; HPAI ; Peramivir ; NAI ; Mouse model
• 刊名：Antiviral Research
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：139
• 期：Complete
• 页码：41-48
• 全文大小：1066 K
• 卷排序：139

文摘

Peramivir showed strong inhibitory activity against H5N1, H7N1 and H7N7 avian influenza viruses. Anti-viral activity of peramivir was decreased in H5N1 virus containing the H275Y mutation. Peramivir prevented lethality in mice infected with H5N1 virus and also H5N1 virus harboring the H275Y mutation. Peramivir reduced viral titers and levels of proinflammatory cytokines in the lungs of mice infected with H5N1 viruses.