Temporally Distinct Six2-Positive Second Heart Field Progenitors Regulate Mammalian Heart Development and Disease

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• 作者：Zhengfang Zhou¹ ; ² ; ⁴ ; Jingying Wang¹ ; ⁴ ; Chaoshe Guo¹ ; Weiting Chang³ ; Jian Zhuang² ; Ping Zhu² ; ^{tanganqier@163.com} ; Xue Li¹ ; ⁵ ; ^{sean.li@childrens.harvard.edu}
• 关键词：Six1 ; Six2 ; Shh ; cardiac outflow tract ; persistent truncus arteriosus ; PTA ; common arterial trunk ; tetralogy of Fallot ; TOF ; intrapericardial arterial trunk ; second heart field ; cardiac neural crest ; progenitor ; high-resolution episcopic microscopy ; HREM ; diphtheria toxin fragment A ; DTA
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：24 January 2017
• 年：2017
• 卷：18
• 期：4
• 页码：1019-1032
• 全文大小：6259 K
• 卷排序：18

文摘

Six2 marks temporally distinct subsets of second heart field progenitors Descendants of Six2+ progenitors are allocated successively to discrete domains of the heart The Shh signaling pathway regulates development of Six2-positive genetic lineages Stage-specific ablation of Six2+ progenitors causes late-onset of heart disease