Graphene oxide supported rhombic dodecahedral Cu₂O nanocrystals for the detection of carcinoembryonic antigen

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• 作者：Taotao Feng ; Xiaoyu Chen ; Xiuwen Qiao ; Zhao Sun ; Haining Wang ; Yu Qi ; ^{qy01_tea@shzu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Chenglin Hong ; ^{hcl_tea@shzu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Graphene oxide ; Rhombic dodecahedral Cu2O nanocrystals ; Gold nanoparticles ; Immunosensor ; Carcinoembryonic antigen
• 刊名：Analytical Biochemistry
• 出版年：2016
• 出版时间：1 February 2016
• 年：2016
• 卷：494
• 期：Complete
• 页码：101-107
• 全文大小：1493 K

文摘

In this work, a simple electrochemical immunosensor was developed for the detection of carcinoembryonic antigen (CEA) based on rhombic dodecahedral Cu₂O nanocrystals–graphene oxide–gold nanoparticles (rCu₂O–GO–AuNPs). GO as the template and surfactant resulting in rCu₂O exhibit improved rhombic dodecahedral structure uniformity and excellent electrochemical performance. Moreover, GO was found to be able to effectively improve the long stability of rCu₂O on the electrode response. Under optimal conditions, the immunosensor showed a low limit of detection (0.004 ng ml⁻¹) and a large linear range (0.01–120 ng ml⁻¹). This work presents a potential alternative for the diagnostic applications of GO-supported special morphology materials in biomedicine and biosensors.