Common variant in PTK2B is associated with late-onset Alzheimer’s disease: A replication study and meta-analyses

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Common variant in PTK2B is associated with late-onset Alzheimer’s disease: A replication study and meta-analyses

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作者：Ya-Qing Li^a ; ¹ ; Meng-Shan Tan^a ; ¹ ; Hui-Fu Wang^a ; Chen-Chen Tan^a ; Wei Zhang^b ; Zhan-Jie Zheng^c ; Ling-Li Kong^c ; Zi-Xuan Wang^a ; Lin Tan^d ; Teng Jiang^e ; Lan Tan^a ; ^{dr.tanlan@163.com" class="auth_mail" title="E-mail the corresponding author} ; Jin-Tai Yu^a ; ^f ; ^{yu-jintai@163.com" class="auth_mail" title="E-mail the corresponding author} ; ^{Jintai.yu@ucsf.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Alzheimer&rsquo ; s disease ; PTK2B ; rs28834970 ; Association study ; Meta-analysis
刊名：Neuroscience Letters
出版年：2016
出版时间：16 May 2016
年：2016
卷：621
期：Complete
页码：83-87
全文大小：760 K

文摘

•: Positive association between rs28834970 and the risk of LOAD was observed in meta-analysis.
•: The difference of allele frequency was evident between LOAD patients and controls in APOE ε4 carriers.
•: PTK2B rs28834970 and APOE may interact to confer risk for LOAD in Han Chinese.

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