High fat diet induces brain insulin resistance and cognitive impairment in mice

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• 作者：Vishal Kothari^a ; Yuwen Luo^a ; Talia Tornabene^a ; Ann Marie O'Neill^b ; Michael W Greene^a ; Thangiah Geetha^c ; Jeganathan Ramesh Babu^a ; ^{jeganrb@auburn.edu}
• 关键词：AD ; Alzheimer disease ; APP ; amyloid precursor protein ; CREB ; CAMP-response element binding ; GFAP ; Glial Fibrillary Acidic Protein ; GTT ; glucose tolerance test ; HFD ; high fat diet ; HFS ; high fat diet with sugar ; HOMA ; homeostatic model assessment ; IDE ; insulin degrading enzyme ; IR ; insulin resistance ; ITT ; insulin tolerance test ; PSD ; postsynaptic density ; RQ ; respiratory exchange quotient ; SEM ; standard error of the mean ; T2DM ; type 2 diabetes
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1863
• 期：2
• 页码：499-508
• 全文大小：1205 K
• 卷排序：1863

文摘

Consumption of high fat diet and sugary drink (HFS) leads to abnormal metabolic phenotype in mice Feeding of HFS also leads to impairment of brain insulin signaling linked with neuroinflammation. Insulin resistant due to HFS associated with biochemical changes in markers related with Alzheimer disease pathology.