Ebola virus disease: An update on current prevention and management strategies

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• 作者：M.A. Trad^a ; ^b ; ^c ; ^{m.a.trad@hotmail.com} ; W. Naughton^g ; A. Yeung^g ; L. Mazlin^d ; M. O&rsquo ; sullivanⁱ ; ^j ; N. Gilroyⁱ ; D.A. Fisher^e ; ^f ; R.L. Stuart^g ; ^h
• 关键词：Ebola ; Management ; Vaccines ; Therapeutics ; Outbreak ; Ebolavirus
• 刊名：Journal of Clinical Virology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：86
• 期：Complete
• 页码：5-13
• 全文大小：560 K
• 卷排序：86

文摘

Management of EBOV infection must emphasize a holistic approach that includes symptomatic control and takes into consideration the psychosocial complexities of having the disease and domestic conditions. International and local agencies setting up treatment centres must be willing to recruit patients into clinical trials, and have structures in place to manage the ethical and medico-legal requirements to facilitate their conduct. Leadership in emergency research is currently lacking, and so are well-designed and practical clinical trials. Conclusions about safety and effectiveness of Ebolavirus disease therapeutics cannot yet be made, but the use of oral therapies has potential especially early on in the disease and in settings were intravenous use of blood products and therapeutics is challenging. Clinics to follow-up on the survivors to establish the natural history of EVD and its long-term sequelae are an opportunity for us to learn more about this disease.