Dabigatran-related platelet thrombin response during triple anti-thrombotic therapy: A matter of time?

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• 作者：Marco Witkowski^a ; Daniel Steffens^a ; Adel Hassanein^a ; Mario Witkowski^b ; Nicolle Krä ; nkel^a ; Andrea Doerner^a ; Julian Friebel^a ; Ulf Landmesser^a ; Ursula Rauch^a ; ^{ursula.rauch@charite.de}
• 刊名：Thrombosis Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：149
• 期：Complete
• 页码：62-63
• 全文大小：228 K
• 卷排序：149

文摘

If and when dabigatran alters platelet aggregation remains controversial. Platelet reactivity was analyzed after coronary stenting in patients on OAC. Dabigatran enhanced the TRAP-induced platelet reactivity after the first dose. Platelet thrombin exposure due to dabigatran dose missing may trigger thrombosis. Co-medication with amiodarone does not alter platelet reactivity.