Lanthanide-based nanocrystals as dual-modal probes for SPECT and X-ray CT imaging

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• 作者：Yongquan Wu ; Yun Sun ; Xingjun Zhu ; Qian Liu ; Tianye Cao ; Juanjuan Peng ; Yang Yang ; Wei Feng ; ^{fengweifd@fudan.edu.cn" class="auth_mail} ; Fuyou Li ; ^{fyli@fudan.edu.cn" class="auth_mail}
• 关键词：EuOF nanocrystals ; Biodistribution ; Bioimaging ; Single photon emission computed tomography (SPECT) ; X-ray computed tomography (CT)
• 刊名：Biomaterials
• 出版年：May, 2014
• 年：2014
• 卷：35
• 期：16
• 页码：4699-4705
• 全文大小：2174 K

文摘

Applications of lanthanide-based nanoparticles for bioimaging have attracted increasing attention. Herein, small size PEG-EuOF:¹⁵³Sm nanocrystals (鈭?聽nm) (PEG聽=聽poly(ethylene glycol)bis(carboxymethyl)ether) combined with the radioactive and X-ray absorption properties were synthesized. The distribution of the PEG-EuOF nanocrystals in living animals was studied by ex聽vivo radioassay, inductively coupled plasma-atomic emission spectrum (ICP-AES) analysis and in聽vivo SPECT imaging, which indicated that the small size PEG-EuOF:¹⁵³Sm had long blood retention time (blood half-life (t_1/2) reach to 4.65聽h) and were eliminated significantly through biliary/gastrointestinal pathway in聽vivo. Meanwhile, benefiting from the high attenuation ability of Eu, the small size PEG-EuOF was successfully applied for lymph node CT imaging, extending the bio-applications of these small nanocrystals. The results of cytotoxicity and in聽vivo toxicity also showed that the PEG-EuOF nanocrystals have relatively low toxicity, which suggest their safety for in聽vivo imaging. The studies provide preliminary validation for the use of PEG-EuOF nanocrystals for in聽vivo bioimaging applications.