Tissue-specific contribution of macrophages to wound healing

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• 作者：Carlos M. Minutti^a ; ¹ ; Johanna A. Knipper^a ; ¹ ; Judith E. Allen^b ; ^{judi.allen@manchester.ac.uk} ; Dietmar M.W. Zaiss^a ; ^{Dietmar.Zaiss@ed.ac.uk}
• 关键词：Macrophage ; Tissue repair ; Extra-cellular matrix ; Inflammation ; Lung ; Skin
• 刊名：Seminars in Cell & Developmental Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：61
• 期：Complete
• 页码：3-11
• 全文大小：781 K
• 卷排序：61

文摘

Macrophages are present in all tissues, either as resident cells or monocyte-derived cells that infiltrate into tissues. The tissue site largely determines the phenotype of tissue-resident cells, which help to maintain tissue homeostasis and act as sentinels of injury. Both tissue resident and recruited macrophages make a substantial contribution to wound healing following injury. In this review, we evaluate how macrophages in two fundamentally distinct tissues, i.e. the lung and the skin, differentially contribute to the process of wound healing. We highlight the commonalities of macrophage functions during repair and contrast them with distinct, tissue-specific functions that macrophages fulfill during the different stages of wound healing.