The work establishes a combined molecular and cellular toxicity evaluation method.
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SDS increased CAT activity through stimulating CAT production in the hepatocytes.
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Binding interactions of SDS with CAT were systematically investigated.
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The binding was majorly driven by electrostatic forces with 13.2 ± 1.24 binding sites.
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SDS preferentially binds to the interface of CAT rather than its active site.
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