文摘
Ruthenium(II)–arene complexes of general formulae [(η6-p-cymene)Ru(L1–3)Cl2], where L1–3 is 3-acetylpyridine (1), 4-acetylpyridine (2) and 2-amino-5-chloropyridine (3), correspondingly, [(η6-p-cymene)Ru(HL4,5)Cl2], where HL4 and HL5 are respectively isonicotinic acid (4) and nicotinic acid (5) and [(η6-p-cymene)Ru(HL6–9)Cl], where H2L6–9 represent 2,3-pyridinedicarboxylic acid (6), 2,4-pyridinedicarboxylic acid (7), 2,5-pyridinedicarboxylic acid (8) and 2,6-pyridinedicarboxylic acid (9), were prepared by the reaction of [(η6-p-cymene)2RuCl2]2 (10) with the corresponding ligand in 1:2 molar ratio in isopropanol. The complexes were characterized by elemental analysis, mass spectrometry, IR and NMR spectroscopies. According to these data the molecules adopt the usual “three-leg piano-stool” geometry which is common for this type of complexes. The structures of 1 and 7 were determined by X-ray crystallography. The complexes revealed low antiproliferative activity in six investigated tumor cell lines (HeLa, B16, FemX, MDA-MB-361, MDA-MB-453 and LS-174). The reaction of 6 with 9-methyladenine was studied by 1H NMR, 1H, 1H COSY and 1H, 1H NOESY spectroscopy.
