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class="h3">Summary
Pheromone signals regulate conspecific behavior and physiology []. Releaser pheromones induce specific behavior by exerting acute effects on the neuronal response, whereas primer pheromones induce physiological changes with long-lasting effects by changing the neuroendocrine status of the recipients. In mammals, although several types of releaser pheromones have been identified [], the identities of primer pheromones, as well as their mechanisms of action, remain largely unknown []. In sheep and goats, the seasonally anestrous endocrine state of females is changed to the estrous state upon exposure to male scents []. This so-called 鈥渕ale effect鈥?is one of the most conspicuous primer pheromone effects in mammals []. In this study, we have identified an olfactory signal molecule that activates the central regulator of reproduction, the gonadotropin-releasing hormone (GnRH) pulse generator, in goats. Using gas chromatography-mass spectrometry to analyze male goat headspace volatiles, we identified several ethyl-branched aldehydes and ketones. We electrophysiologically demonstrated that one of these compounds, 4-ethyloctanal, activates the GnRH pulse generator in female goats. This is the first report of an olfactory molecule that has been shown to activate the central reproductive axis, and this discovery will provide a new direction for primer pheromone research.
