Tolfenamic acid downregulates β-catenin in colon cancer

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Tolfenamic acid downregulates β-catenin in colon cancer

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作者：Taekyu Ha^a ; ¹ ; Zhiyuan Lou^a ; ¹ ; Seung Joon Baek^b ; Seong-Ho Lee^a ; ^{slee2000@umd.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Tolfenamic acid ; β-catenin ; Smad2 ; Colon cancer
刊名：International Immunopharmacology
出版年：2016
出版时间：June 2016
年：2016
卷：35
期：Complete
页码：287-293
全文大小：886 K

文摘

•: Anticancer mechanism of tolfenamic acid is proposed.
•: The mechanism relies on activating proteasomal degradation of β-catenin.
•: Smad2 mediates tolfenamic acid-induced downregulation of β-catenin.

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