Promoter variation in the catechol-O-methyltransferase gene is associated with remission of symptoms during fluvoxamine treatment for major depression

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• 作者：Naoki Fukui ; Yutaro Suzuki ; Takuro Sugai ; Junzo Watanabe ; Shin Ono ; Nobuto Tsuneyama ; Toshiyuki Someya ; ¹ ; ^{psy@med.niigata-u.ac.jp" class="auth_mail}
• 关键词：COMT ; Depression ; Fluvoxamine
• 刊名：Psychiatry Research
• 出版年：30 August 2014
• 年：2014
• 卷：218
• 期：3
• 页码：353-355
• 全文大小：193 K

文摘

We investigated the association between remission of depressive symptoms in fluvoxamine treatment and catechol-O-methyltransferase (COMT) gene. Sixteen SNPs in the COMT gene were investigated in 123 outpatients with major depression. Three single nucleotide polymorphisms located in the 5′ region were associated with remission in fluvoxamine-treated outpatients with moderate to severe depression.