Total synthesis of the COPD biomarker desmosine via Sonogashira and Negishi cross-coupling reactions

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• 作者：Hiroto Yanuma ; Toyonobu Usuki
• 关键词：Desmosine ; Biomarker ; Elastin ; Total synthesis ; Sonogashira cross-coupling ; Negishi cross-coupling
• 刊名：Tetrahedron Letters
• 出版年：2012
• 出版时间：31 October, 2012
• 年：2012
• 卷：53
• 期：44
• 页码：5920-5922
• 全文大小：210 K

文摘

Desmosine, a crosslinking pyridinium amino acid of elastin, is an attractive biomarker for the diagnosis of chronic obstructive pulmonary disease (COPD). In this study, the total synthesis of (+)-desmosine is reported utilizing chemo- and regioselective Sonogashira and Negishi cross-coupling reactions in 15 % yield over six steps.