TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression

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TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression

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作者：Xian Zhang¹ ; ² ; ³ ; Chien-Feng Li⁹ ; ¹⁰ ; Ling Zhang² ; ¹¹ ; Ching-Yuan Wu² ; ¹² ; Lixia Han² ; ³ ; Guoxiang Jin¹ ; ² ; Abdol Hossein Rezaeian² ; Fei Han¹ ; ² ; ³ ; Chunfang Liu¹ ; ² ; Chuan Xu¹ ; ² ; Xiaohong Xu² ; Chih-Yang Huang⁴ ; ⁵ ; Fuu-Jen Tsai⁶ ; ⁷ ; Chang-Hai Tsai⁵ ; ⁸ ; Kounosuke Watabe¹ ; Hui-Kuan Lin¹ ; ² ; ⁴ ; ⁵ ; ¹³ ; ^{hulin@wakehealth.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：p53 mitochondrial translocation ; K63-linked ubiquitination of p53 ; p53 transactivation ; TRAF6 inhibits apoptosis ; p53 K24 ubiquitination ; genotoxic stress ; tumor suppression ; colorectal cancer ; MCL1/BaK ; p300 recruitment
刊名：Molecular Cell
出版年：2016
出版时间：17 November 2016
年：2016
卷：64
期：4
页码：803-814
全文大小：3555 K

文摘

•: TRAF6 restricts p53 mitochondria localization and spontaneous apoptosis
•: TRAF6 promotes K63-linked ubiquitination of p53 at K24
•: K63-linked ubiquitination of p53 in cytosol attenuates tumor suppressive function
•: Genotoxic stress promotes TRAF6 phosphorylation and TRAF6 translocation

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