In silico characterization of TTHA0596: A potential Zn^{2 +} binding protein of ATP-binding cassette transporter

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• 作者：Suraj Kumar Mandal ; Monika Chandravanshi ; Prerana Gogoi ; Shankar Prasad Kanaujia ; ^{spkanaujia@iitg.ernet.in} ; ^{spkanaujia@gmail.com}
• 关键词：APBS ; adaptive Poisson Boltzmann solver ; ATP ; ATP-binding cassette ; Fe ; iron ; HP ; hypothetical protein ; Mn ; manganese ; MSA ; multiple sequence alignment ; NBD ; nucleotide binding domain ; ORF ; open reading frame ; PMBP ; periplasmic metal binding protein ; RMSD ; root mean square deviation ; SBP ; substrate binding protein ; TMD ; transmembrane domain ; Zn ; zinc
• 刊名：Gene Reports
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：6
• 期：Complete
• 页码：132-141
• 全文大小：2242 K
• 卷排序：6

文摘

TTHA0596 is a metal binding protein belonging to cluster A-I family of SBPs. Evolutionarily, TTHA0596 is closer to Zn2 + and Mn2 + binding SBPs rather than Fe2 +/3 + binding SBPs. TTHA0596 belongs to group I Zn2 + binding SBPs which exhibit additional affinity for Mn2 + ions. TTHA0596 protein may bind both Zn2 + and Mn2 + ions.