Risk Factors and Outcomes of Infections by Multidrug-Resistant Gram-Negative Bacteria in Patients Undergoing Hematopoietic Stem Cell Transplantation

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• 作者：Francesca Patriarca¹ ; ^{francesca.patriarca@asuiud.sanita.fvg.it} ; Chiara Cigana¹ ; Dozzo Massimo¹ ; Davide Lazzarotto¹ ; Antonella Geromin¹ ; Miriam Isola² ; Marta Lisa Battista¹ ; Marta Medeot¹ ; Michela Cerno¹ ; Alessandra Sperotto¹ ; Anna Candoni¹ ; Massimo Crapis³ ; Assunta Sartor⁴ ; Claudio Scarparo⁴ ; Matteo Bassetti³ ; Renato Fanin¹
• 关键词：Infections ; Multidrug-resistant gram-negative bacteria ; Hematopoietic stem cell transplantation ; Gut colonization
• 刊名：Biology of Blood and Marrow Transplantation
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：23
• 期：2
• 页码：333-339
• 全文大小：464 K
• 卷排序：23

文摘

We reported the results of a 3-year surveillance program of infections by multidrug-resistant gram-negative (MDR GN) bacteria in a transplant unit. Cumulative incidence of MDR GN infections was 10.5%. Allogeneic transplant and colonization by MDR GN bacteria at admission to the transplant unit were significantly associated with an increased risk of infection. Patients who proceeded to allogeneic transplant and developed MDR GN infections had a significantly higher TRM and a poorer OS compared with patients without MDR infections. The risk-to-benefit ratio of performing an allogeneic transplant could be carefully evaluated in patients colonized with MDR GN bacteria.